A whole genome screen for association with multiple sclerosis in Portuguese patients.

نویسندگان

  • M Santos
  • J Pinto-Basto
  • M E Rio
  • M J Sá
  • A Valença
  • A Sá
  • J Dinis
  • J Figueiredo
  • L Bigotte de Almeida
  • I Coelho
  • S Sawcer
  • E Setakis
  • A Compston
  • J Sequeiros
  • P Maciel
چکیده

Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.

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عنوان ژورنال:
  • Journal of neuroimmunology

دوره 143 1-2  شماره 

صفحات  -

تاریخ انتشار 2003